mesenchymal stem cell differentiation

mesenchymal stem cell differentiation

Mesenchymal stem cells (MSCs) are undifferentiated multipotent cells that possess great potential in tissue regeneration and cell-based therapy due to their multipotency. Application of MSCs requires their isolation and direction of their differentiation into the appropriate lineage. Creative Biolabs offers customized services for reliable in vitro induction of MSCs into osteogenic, adipogenic, muscular, and chondrogenic lineages.

Differentiation Potential of MSCs
MSCs have the ability to differentiate into a large number of specialized cell types following specific signals (e.g., Wnt and redox signals, microRNAs, reactive oxygen species). These include mesodermal (osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes), ectodermal (neuronal cells) and endodermal (hepatic, pancreatic, respiratory epithelium) lineages. Moreover, a fully differentiated cell from one lineage can switch into another mature cell type of MSCs, which is a phenomenon called genetic reprogramming or transdifferentiation. As a result, MSCs derived from different tissues can be readily isolated and expanded for both basic and biomedical research. It has to be noted that MSCs from different tissues have exhibited differences in their differentiation capacity and regeneration potential. Besides, increased age of donor and passaging of cultured MSCs also decrease differentiation potential.