Clinical Implications of Non-IgG Antibodies in Transplant Rejection

Organ transplantation provides an avenue for patients with end-stage organ failure to regain health and improve their quality of life. However, transplant rejection, characterized by the recipient's immune system attack on the donor organ remains a constant threat. Antibodies produced by the recipient's immune system are key players in this process. Classically, IgG antibodies have been studied extensively as potential contributors to post-transplant complications. Nonetheless, a focus on IgG responses may neglect a potentially relevant humoral response. Recent findings suggest that non-IgG antibodies, particularly IgM and IgA, could equally play crucial roles in mediating graft rejection.

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