Models for Studying Microglia
The three-dimensional mini-brains closely mimic the architecture of the human brain and are particularly valuable for studying microglia.
Microglia-Containing Brain Organoids
Human brain organoid tissues containing microglia can recapitulate their interactions with neurons, astrocytes and other brain cells. This breakthrough technique involves differentiating microglia from human pluripotent stem cells and integrating them into three-dimensional organoid structures.
Co-Culture Systems
The co-culture system provides a versatile method to study microglia. In these systems, microglia can bind to neurons or other nerve cells. This approach allows microglia-neuron interactions to be examined in a controlled environment.
Chimeric Organoids
By creating organoids with different ratios of microglia to neurons, astrocytes, or other nerve cell types, researchers can study how microglia affect the development and function of neural networks.
3D Microfluidic Systems
Microfluidic devices can be integrated with brain organoids to study microglia behavior under dynamic conditions. These systems can control the delivery of various factors to assess microglia responses in real time. Researchers can simulate inflammatory or infectious scenarios to gain a deeper understanding of the role of microglia in immune responses within the brain.
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