A new era of cancer immunotherapy has begun. Chimeric antigen receptor T (CAR-T) cells, which have been genetically engineered to recognize the CD-19 antigen of B cells, have been successfully treated in various clinical trials for relapsed and refractory B cell malignancies. However, this treatment has several disadvantages. Side effects such as cytokine toxicity, tumor lysis syndrome, effects on healthy tissues, B cell hypoplasia, and genotoxicity can be fatal.
To avoid these drawbacks, CAR technology is being applied to other immune cells, such as natural killer (NK) cells. Unlike T cells, NK cells can be more easily fine-tuned to prevent treatment-related toxicity and immune-mediated adverse events. NK cells have great clinical significance because they contribute to graft-vs-leukemia / graft-vs-tumor effect but are not responsible for graft-vs-host disease. NK cells can be generated from various sources, such as cord blood, bone marrow, human embryonic stem cells, and induced pluripotent stem cells.
Full Article: CAR-NK vector
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