Introduction of Cell Line Models
The human brain is a complex organ composed of a variety of cell types and signaling pathways. Since mature neurons do not undergo cell division again, it is necessary to establish immortalized secondary cell lines derived from neuronal tumors, that is, to acquire the ability to generate in vitro cultures of neuronal cells. The established molecular tools and stem cell line models can mimic the physiology of the brain for a better understanding of neurological diseases and treatment strategies. Based on our excellent primary cells, stem cells, and other cell line models, it would be possible to create in vitro culture systems that mimic in vivo environments.
Cell Line Models for Neuroscience Research
Characterized by the functional deterioration of neurons, neurodegenerative diseases present severe implications for individuals and society. Creative Biolabs has developed several culture systems to study the pathogenesis of neurodegenerative diseases. For example, the human neuroblastoma cell line SH-SY5Y has been widely used for the research of Parkinson's disease (PD); the Lund human mesencephalic (LUHMES) immortalized cell line can be used for neurotoxicity studies. Our diverse cell models allow better characterization of disease markers and in vivo physiological conditions. In addition, our model also improves the understanding of human neurodegenerative diseases and can better characterize pathological mechanisms.
It is worth noting that 3D cultures, organotypic cultures, as well as organoids can be served as a complement to cell line models to further improve the precision and confidence of research.
Learn more: neuroblastoma cell lines
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