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Background
Studies of rabbit MHC molecular have identified the complexity of rabbit leukocyte antigen (RLA) of class I, class II and class III genes as their DNA sequence are homologous to those of humans. The RLA class I genes is made up of 8 to 14 genes, depending on the haplotype. The class II genes are also very similar to the homologous genes of human HLA-DR, -DQ, -DP, and -DO genes. Many class III genes have been identified, including the TNF A and B genes. In contrast to human MHC, the localization of class I and class II genes are contiguous in rabbits. According to the restriction fragment length polymorphism (RFLP) of class I and class-II (DRA, DQA) genes, the molecular DNA typing of rabbit MHC has allowed the definition of 13 haplotypes. Another polymorphism, characterized by the insertion/deletion of large DNA fragments, has been described in the class II gene region (Figure 1).
Learn more: Rabbit RLA Genotyping
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