Because most therapeutic proteins suffer from poor pharmaceutical properties, a key element for the satisfactory development of novel protein drugs is to fully measure their half-life and pharmacodynamic behavior before performing clinical trials. However, many recombine proteins have complex interactions with the metabolism system, which behaves differently in human and wild animals. Therefore, humanized animal models are developed to accurately predict human drug exposure and pharmacokinetics. As a leading service provider in therapeutic proteins area, Creative Biolabs keeps up with the time and launches animal models development service for half-life assay. Our highly experienced staff can offer professional and meticulous service to accelerate your drug research process.
Introduction of Animal Models Development for Half-life Assay
Exactly measurements of drug metabolism and pharmacokinetics is key to drug discovery, especially in the field of therapeutic antibody drugs. While accurate prediction of half-life in human body shows more importance due to high in vivo degradation rate of most extrinsic proteins. While many in vitro modeling approaches exist, these simply cannot substitute for data obtained from appropriate animal models. Therefore, an urgent need exists to develop better in vivo animal models more predictive of human drug response.
The most effective means to develop half-life assay animal models is humanizing domesticated mouse strains, usually by genetic modification or organ transplantation. These humanized animals showing a metabolic system like humans act as important roles in establishment of in vivo half-life assay platform in preclinical studies. Through the validation of many groups and top journals in drug research field, lots of optimized animal models are applied in half-life assay.
Learn more: Animal Model Development for Half-life Assay
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