Small molecule β-Lactams hapten with good immunogenicity are of great interest for the monoclonal antibodies (mAbs) or polyclonal antibodies (pAbs) preparation. Armed with comprehensive molecular simulation softwares and extensive track record of successful projects in developing small hapten antigen for immunization, Creative Biolabs now provides customized β-Lactams hapten design, modification, and synthesis services for our global clients.
Introduction of β-Lactam Antibiotics
β-Lactam antibiotics are the oldest antimicrobial agents and have the advantages of low toxicity, wide indications, good clinical efficacy, strong anti-bacterial activity in inhibiting the activity of bacterial peptidoglycan transpeptidase and preventing the formation of cell walls. The structure of β-Lactam antibiotics consists of nucleus and side chain. The nucleus contains a four-membered β-Lactam cycle, which fused with the second five- or six-membered ring through N atom and three carbon atoms nearby. According to the differences in parent nuclear structure, β-Lactam antibiotics can be divided into families of penicillins (PENs), cephalosporins (CEPs), monobactams, cephamycins (methoxy cephalosporins, oxacephems), and carbapenems. The β-Lactam ring is a target for nucleophilic attack by free amino groups of proteins, leading to ring-opening and covalent amide bonding of the penicilloyl group. β-Lactam ring is the most unstable part of the chemical structure of β-Lactam antibiotics. Acids, alkalis, some heavy metal ions (oxidant), and exist of alcohols or penicillinase can accelerate the degradation of β-Lactam ring.
Learn more: beta-lactam examples
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