Background of Non-IgG BsAb

A unique class of antibody known as BsAb is capable of reacting with two distinct targets at once, such as cells, ligands, receptors, antigens, and epitopes. Bispecific single-domain antibodies, bispecific diabodies, bispecific Fab domains, and so on are examples of the various structures and formats that can be created for BsAbs (see Fig. 1). These structures and formats are generally classified into two classes: IgG-like (structures that contain an Fc region) and non-IgG-like (structures lacking an Fc region). Since these broad-spectrum BsAbs bind to both a target and a cytotoxic cell at the same time, they are highly effective for cancer immunotherapy and are widely used for diagnosis, prophylaxis, drug delivery, and therapy.

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